Abstract
An electron microscopic study was made on neuroaxonal lesions in the anterior motoneurons of the lumbar spinal cord in IDPN-treated rats which manifested the permanent “waltzing syndrome” during the stages of axonal balloon formation. The following observations and discussion were made. 1. Within the axonal balloons, there were focal accumulations of usual axoplasmic constituents, viz., neurofibrils, mitochondria, and small vesicles. 2. The balloons, outlined by a thin myelin or axolemmal layer, or axoplasmic contents without definite membrane structure, were often surrounded by edematous spaces filled with granular material. 3. Distal to the balloons, there were segmental accumulations of degenerating mitochondria, vesicles, and also of dense complex bodies within the myelinated portions of axons. 4. No significant alterations were observed in the perikarya of the anterior motoneurons. 5. The present study seems to support a previously held hypothesis of a mechanism of “primary axostasis” as the cause of the lesions as well as of the waltzing syndrome. The intra-axonic dense complex bodies, resembling pigment granules, would provide a plausible explanation for the permanence of the induced syndrome.
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