Abstract
Microprojections, and specifically, microvilli, are present on many cell types. The cells which have them are often involved in either secretion or absorption In 1975 Bowman and Daniel1 reported that increased numbers of microvilli were present on WI-38 human fibroblasts in vitro at higher population doubling levels. A new cell strain, IMR-90 was recently developed to supplement the depleting supplies of WI-38. We wished to determine if increased numbers of microvilli were to be found on aging cells in general and began by examining the IMR-90. Indeed, this cell strain was also found to show higher indices with increased population doubling levels2 .
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