Abstract
Tubular structures and double-shelled spherical particles were regularly observed in nuclei of frog renal adenocarcinoma cells which contained the herpes-type virus of this tumor. Morphological observations and virus development studies have indicated that the spherical particles give rise to 35-mμ tubules, which subsequently serve as cores for 65-mμ tubules. The outer sheath of the larger tubule consists of capsomeres similar to those comprising virus capsids, indicating a relationship between tubular structures and virus particles. A morphological similarity between spherical particles and an internal double-shelled structure of immature virus particles suggests that the spherical particles are also virus-related. Evidence is presented which indicates that both the spherical particles and tubular forms are aberrant structures regularly produced during virus replication in the frog kidney tumor.
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