Abstract
ABATRACT Electrolytes are of great importance in cell metabolism because they are important cofactors or coenzymes needed for normal functioning of cells. The disturbances of these electrolytes result in changes of cell pH and acid base balance. In order to determine the electrolytes changes following feed and water deprivation in male rats, a total of ten (n=10) male albino rats weighing (152 ± 3.50)g housed in metallic cage were used for this study. The rats were deprived of feed and water consecutively for six days. On the third and sixth days blood samples were obtained for electrolytes studies in the plasma and in the erythrocytes. There were significant increases (P<0.05) in plasma sodium, potassium, calcium, magnesium, chloride and bicarbonate concentrations in comparison to the basal parameters while significant decreases (P<0.05) in erythrocytes sodium, potassium, calcium, magnesium, chloride and bicarbonate concentrations in comparison to the basal parameters were observed. It can be concluded that deprivation of male albino rats of food and water for six consecutive days resulted in perturbation, stress, dehydration and redistribution of electrolytes in various compartments of the cell
Highlights
Deprivation of food and water are common features of biomedical and behavioral research as well as a method of standardization of animals for experimental and assay procedures
Haematological and some biochemical changes were reported when male rats were deprived of feed and water for six consecutive days
Other biochemical changes observed were stress induced increased activities of liver enzymes such as aspartate aminotransferase and alanine aminotransferase (Lin et al, 2005; Okediran et al, 2021), increase lipid metabolism as a result of activation of hormone sensitive lipase (Mahboob et al, 1999), rapid mobilization and hydrolysis of triglyceride in adipose tissue, causing a rise in plasma free fatty acid concentration (Moitra et al, 1998; Kersten et al, 1999) to generate energy since glucose is in short supply
Summary
Deprivation of food and water are common features of biomedical and behavioral research as well as a method of standardization of animals for experimental and assay procedures. Feed and water are very essential for well-being of the animals because it contains carbohydrates, proteins, lipids, vitamins and minerals in Haematological and some biochemical changes were reported when male rats were deprived of feed and water for six consecutive days. Haematological and biochemical changes were reported in male rats subjected to feed and water deprivation for six consecutive days (Okediran et al, 2021), electrolytes play significant role in maintaining various biochemical activities within the cell either as a cofactor or coenzymes in biochemical pathways. They contribute in maintaining the conformation of enzymes most especially membrane bound enzymes. This study is to unravel some of the changes that might affect the electrolytes when male rats were deprived of feed and water for six consecutive days
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