Abstract
A glassy carbon (GC) electrode modified by multi-walled carbon nanotubes (MWNTs) and bis(pyterpy)iron(II) thiocyanate complex (pyterpy = 4'-(4-pyridyl)-2,2':6',2''-terpyridine) was investigated by voltammetric methods in acetate buffer solution (pH 5). Performances of the iron(II)-complex/MWNTs modified electrode were evaluated with differential pulse voltammetry and scanning electron microscopy (SEM). The modified glassy carbon electrode shows an excellent electrochemical response for ascorbic acid (AA), dopamine (DA) and uric acid (UA). The differential pulse voltammetry oxidation peaks for AA and DA, DA and UA, AA and UA are separated by 210, 136 and 346 mV, respectively. This separation permits the simultaneous determination of AA, DA and UA. The anodic peak currents of AA, DA and UA increase linearly with concentration in the range of 1.10×10-5-1.50×10-3 mol L-1, 9.0×10-7-1.20×10-3 mol L-1 and 2.00×10-6-1.50×10-3 mol L-1, respectively, with a correlation coefficient (r) always higher than 0.998. In addition, the modified electrode also shows good sensitivity and stability. Satisfactory results were achieved for the determination of AA in vitamin C tablets, DA in dopamine injection solution and UA in human blood serum samples
Highlights
There has been a considerable effort in the development of voltammetric methods for the determination of ascorbic acid (AA), dopamine (DA) and uric acid (UA) in biological samples
We report the electrochemical behavior of ascorbic acid, dopamine and uric acid on the surface of the iron(II) complex-multi-walled carbon nanotubes (MWNTs) modified glassy carbon (GC) electrode
The iron(II)-complex/multi-walled nanotubes modified GC electrode was first characterized by transmission electron microscopy (TEM) and scanning electron microscopy (SEM)
Summary
There has been a considerable effort in the development of voltammetric methods for the determination of ascorbic acid (AA), dopamine (DA) and uric acid (UA) in biological samples.
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