Abstract
In this research, we investigated the electrochemical behaviors of conducting poly(thionine) (PTH) on glassy carbon electrode (GCE) for the interference-free detection of dopamine (DA). The PTH films on GCE were prepared in two methods: direct potential sweeping (single step, PTH-S), or a constant potential oxidation of GCE followed by potential sweeping (double step, PTH-D). Our electrochemical investigation revealed that the simple variation of the electropolymerization conditions dramatically changed the PTH formation mechanism without altering the chemical structure of the polymers as well as the catalytic activity for the oxidation of DA in the presence of ascorbic acid (AA) and uric acid (UA). The PTH-D exhibited higher sensitivity for the detection of DA compared to the PTH-S, which can be attributed to the higher accumulated surface charge/polymer amount on the PTH-D films compared to the PTH-S. The PTH-S could easily suppress the signals of AA and UA in the presence of DA, while, the PTH-D could easily separate the oxidation signals of AA, DA, and UA with higher sensitivity. These interesting features will help the researchers to control the sensitivity for DA oxidation and other analytes by using PTH and other conducting polymers.
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