ELECTROCHEMICAL SENSORS BASED ON POLY (L-PHENYL ALANINE) FILM ON MWCNT FOR DETERMINATION OF TPS

Abstract

In this study, cyclic voltammetry (CV) is presented with a sensitive electrochemical technique for the assessment of the anti-cancer medicine Toposar (TPS). The electrode was formed on the surface of a modified glassy carbon electrode with MWCNT using a coating of L-phenyl alanine to become the new electrode in a formula (PPA-MWCNT/GCE). PPA was polymerized at pH 8.0, which showed advanced advantages for the study and estimation of TPS electroanalysis treatment. A group of factors on the bare glassy carbon electrode were studied to enhance the electrode 's work to study TPS, including these factors(Influence of pH, calibration curve, the stability of the electrode, scan rate, deposition potential, voltage step, equilibration time, deposition time). As a result of the electrode development, the stability of the prepared electrode was observed with the PPA layer with the Morphology of the layer by the SEM analysis showing the morphology of PPA/GCE and MWCNTs/PPA/GCE by SEM, respectively. The PPA film width on TPS response has higher sensitivity on the surface of MWCNTs/PPA/GCE compared to GCE and increased redox reversibility with 8 cycles number. The CV of 5.0 nM TPS on GCE with scanning rates of between 50 and 400 mV.s?1 This reaction was predicted for an irrevocable electrode mechanism. A comparison was made between the TPS CVs on the MWCNPs, and the PPA modified electrode with the bare GCE at pH 7.0 with a scan rate of 100 mV.s?1, the oxidation current is 11.18 times higher than the comparable one on the bare GCE.