Abstract
Portable electrochemical sensors based on noble metal nanoparticles (МеNPs) for the quantitative determination of hydrogen peroxide (H2O2) and sulfur-containing amino acids (cysteine, methionine, glutathione) are discussed. These sensors have high sensitivity (pM), with low sample requirements (<50 μl). This article discusses methods for producing sensors based on silver and gold nanoparticles and their application in voltammetry. It is shown that the sensitivity of H2O2determination on a sensor based on silver nanoparticles (AgNPs) depends on their size. Their size is determined by the reducing agent. Sensors based on AgNPs of spherical shape with the smallest size from 0.5 to 17.5 nm have the highest sensitivity for determining H2O2, but a narrow range of determined concentrations. Sensors on medium-sized AgNPs have optimal metrological characteristics. Their size is from 10 to 55 nm, less sensitive, but with a wide range of determined concentrations from 0.1 to 1 nm H2O2. The linearity of the range of glutathione concentrations is 1.0-10.0 pM. The linearity of the range of determined concentrations of methionine is 1–26 рМ.
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