Abstract
The electropolymerisation of DL-alanine was carried out at the surface of carbon paste electrode by cyclic voltammetric (CV) technique. The fabricated electrode was used for the electrocatalysis of adrenaline at neutral pH. The key parameters like influence of scan rate and concentration reveals the adsorption controlled process. The lower limit of detection was calculated to be 28.0 nM in the linear range of 10 to 60 μM by CV technique. Further, the poly (alanine) modified carbon paste electrode can be used for the selective determination of adrenaline in presence of acetaminophen. Overall, the fabricated electrode can be used as a promising analytical sensor in the determination of adrenaline in pharmaceutical and biological samples.
Highlights
Adrenaline (AD) is one of the neurotransmitter catecholamine found in the mammalian central nervous system; exist in the form of large organic cations in the nervous tissue and biological body fluid [1]
Several methods have been reported for the determination of adrenaline such as high performance liquid chromatography [4,5,6], fluorometry [7,8,9] chemiluminescence [10,11], capillary electrophoresis [12] and spectrophotometry [13]
In the continuation of our study, we proposed convenient method for the selective and sensitive detection of adrenaline in the presence of acetaminophen, which has a significant attraction in biological and chemical fields
Summary
Adrenaline (AD) is one of the neurotransmitter catecholamine found in the mammalian central nervous system; exist in the form of large organic cations in the nervous tissue and biological body fluid [1]. Many analytical methods are reported to determine the acetaminophen concentration such as spectrophotometry [21], high performance liquid chromatography [22], and voltammetry [23]. These techniques are generally expensive and time-consuming. After electropolymerisation the modified electrode was rinsed in double distilled water and stored in 0.2 M PBS (pH 7.0) until use
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