Abstract
Herein, an electrochemical sensor for detection of indole was fabricated based on Pd nanoparticles modified Metal-Organic Framework Cr-MIL-101 (Pd@Cr-MOF) and ionic liquid (IL). The electrochemical behavior of indole was investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at the surface of the modified electrode. The sensor was developed by incorporating of ultra-small nano-sized palladium particles stabilized on metal–organic framework Cr-MIL-101 and 1-hexyl-3-methylimidazolium chloride in the carbon paste electrode (CPE). The synthesized Pd nanoparticles modified Metal-Organic Framework Cr-MIL-101 (Pd@Cr-MOF) was characterized using Brunauer-Emmett-Teller (BET), EDS, XRD, SEM and TEM techniques. The Pd@Cr-MOF/IL/CPE exhibited the good sensitivity towards indole compared to the unmodified electrode. The linear range for determination of indole by this sensor was found to be 1 to 1100 nM with a detection limit of 0. 3 nM. Also, the proposed sensor was successfully applied for monitoring of indole in human serum sample and satisfactory results were obtained. Ultimately, high performance liquid chromatography (HPLC) method was applied for the validation of the electrochemical method for the determination of indole in human serum sample.
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