Abstract
A novel tantalum pentoxide nanoparticle-electrochemically reduced graphene oxide nanocomposite-modified glassy carbon electrode (Ta2O5-ErGO/GCE) was developed for the detection of oxytetracycline in milk. The composition, structure and morphology of GO, Ta2O5, and Ta2O5-ErGO were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). Oxytetracycline electrochemical behavior on the bare GCE, GO/GCE, ErGO/GCE, and Ta2O5-ErGO/GCE was studied by cyclic voltammetry. The voltammetric conditions (including scan rate, pH, deposition potential, and deposition time) were systematically optimized. With the spacious electrochemical active area, the Ta2O5-ErGO/GCE showed a great magnification of the oxidation signal of oxytetracycline, while that of the other electrodes (GCE, GO/GCE, ErGO/GCE) could not reach the same level. Under the optimum conditions, the currents were proportional to the oxytetracycline concentration in the range from 0.2 to 10 μM, and a low detection limit of 0.095 μM (S/N = 3) was detectable. Moreover, the proposed Ta2O5-ErGO/GCE performed practically with satisfactory results. The preparation of Ta2O5-ErGO/GCE in the current work provides a minor outlook of detecting trace oxytetracycline in milk.
Highlights
Antimicrobial residues in food products of animal origin have become a great global safety concern
Voltammograms were obtained through a cyclic voltammetry (CV) electrochemical technique using a CHI 660E electrochemical workstation from the company of Shanghai Chenhua Instruments, China
The experiment conducted involved the use of glassy carbon electrode (GCE) as the working electrode, which was fabricated with a Ta2O5 NPs-ErGO, platinum electrode and saturated calomel electrode as the counter and reference electrodes respectively
Summary
Antimicrobial residues in food products of animal origin have become a great global safety concern. There are promising results in the use of Ta2O5 NPs in the electrochemical sensing of toxic chemical substances in foods and human samples [37,38]. In sensing chemical contaminants such as food additives and antibiotic residues in food and food products, more effort is needed in exploring the potential of the material as other transition metal oxide nanoparticles have shown good results in the mentioned area. It has been identified to contain few amounts oflactone, quinone, carboxy, carbonyl, and phenol at the edges of the sheet These functional groups have a significant effect on GO electrochemical properties and activity [42]. Zhou et al and Sun et al [29,37] have reported the successful application of the Ta2O5/GO nanocomposite synergistic effects inelectrochemical sensing and photocatalysis, respectively.
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