Abstract
The construction and electrochemical response characteristics of poly(vinyl chloride) matrix ion‐selective electrodes (ISEs) for papaverine hydrochloride are described. The membranes incorporate ion association complexes of papaverine with tetraphenylborate {[B(C6H5)4]−}, picrate {[C6H2(NO2)3O]−}, tetraiodomercurate [(HgI4)]2−, tetraiodobismuthate [(BiI4)−], Reinecke salt {[Cr(NH3)2(SCN)4]−} and heteropolycompounds of Keggin structure–molybdophosphoric acid [H3(PMo12O40)], tungstophosphoric acid [H3(PW12O40)], molybdosiliconic acid [H4(SiMo12O40)], and tungstosiliconic acid [H4(SiW12O40)] as electroactive materials for ionometric sensor controls. These ISEs show linear response for papaverine hydrochloride over the range from 1×10−5 up to 5×10−2 mol/l with cationic slopes from 42 up to 58 mV per concentration decade. These ISEs exhibit fast response time (up to 1 min), low determination limit (up to 1×10−5 M), good stability (3–5 weeks) and reasonable selectivity. The ISEs were used for direct potentiometry and potentiometric titration {Na[B(C6H5)4]} of papaverine hydrochloride in pharmaceutical preparations. Results with mean accuracy of 98.6±0.9% of nominal were obtained, which correspond well to data obtained with the European Pharmacopoeial method.
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