Electrochemical oxidation of Atorvastatin using graphene oxide and surfactant-based sensor

Abstract

In this work, graphene oxide and sodium dodecyl sulphate-based carbon paste electrode (GO-SDS/CPE) was developed for the determination of Atorvastatin (ATR) employing voltametric techniques. The surface topography of a modifier material i.e., graphene oxide was studied employing Atomic force microscope (AFM) and Scanning electron microscope (SEM). The inclusion of GO and anionic surfactant in carbon paste electrode (CPE) caused a remarkable increase in peak current of ATR in pH 5.0 of Phosphate buffer solution. The process was predominantly governed by adsorption with the involvement of 2 electrons and 1 proton in the reaction. Quantification of ATR was carried out in the concentration range 0.8–9.0 µM and detection limit was computed. The utility of the fabricated electrode was investigated for clinical and biological samples and the stability of an electrode was also studied.