Electrochemical evaluation and voltammetric determination of laxative drug bisacodyl on boron-doped diamond electrode

Abstract

Electroanalytical chemistry plays a very important role concerning the development of environmentally friendly and time-saving analytical methods. This work reports the first voltammetric determination of bisacodyl (BIS) using boron-doped diamond electrode (BDDE). On the cathodically pretreated BDDE, BIS presented an irreversible and diffusion controlled anodic peak at 1.55 V (vs Ag/AgCl (3.0 mol L–1 KCl)) in BR buffer solution (pH 5.0). Using optimized experimental conditions, the anodic current was linear with the BIS concentration range of 1.00–44.0 μmol L–1, with limit of detection of 0.343 μmol L–1. The viability of the proposed method was successfully evaluated by quantification of BIS in commercial pharmaceutical formulations and the accuracy of the developed analytical procedure was statistically proven by comparison with a validated spectrophotometric method.