Electrochemical determination of carbamazepin in the presence of paracetamol using a carbon ionic liquid paste electrode modified with a three-dimensional graphene/MWCNT hybrid composite film

Abstract

In this research work, a carbon ionic liquid paste electrode (CILPE) based on butyl-3-methylimidazolium bis (trifluoromethylsulfonyl) imide ([bmim] NTF2) was fabricated and further modified with graphene/multiwall carbon nanotube (GR/MWCNT) hybrid composite. The modified electrode (GR/MWCNT/CILPE) was used for measurement of carbamazepine (CBZ) in the presence of paracetamol (PA) with an excellent electrochemical catalytic behavior. The application of the electrode was investigated by cyclic voltammetry and differential pulse voltammetry. The oxidation peak currents of CBZ and PA were linear at the ranges of 1–60μM and 2–80μM, respectively. Also, the detection limits for CBZ and PA were 0.233μM and 0.262μM, respectively. The proposed sensor was successfully applied for the determination of CBZ and PA in tablet and urine samples.