Abstract
In order to assay sympatomimetic drugs (heptaminol and related compounds), a derivatization procedure with the use of o-phthalaldehyde (OPA) and various thiols was developed. Some structural assignments of the OPA-amino drug adducts are proposed and the electroactive properties of these substituted isoindolic products were investigated by voltamperometry. High-performance liquid chromatographic separations were carried out on a reversed-phase column (LiChrosorb RP-18) with phosphate buffer (pH 7.2)-methanol mixtures as mobile phase. For detection , either UV spectrophotometry (Îť = 340 nm) or amperometry (+ 0.9 V) was used. By the latter levels in the picomole range were detectable.
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