Abstract
The rapid electrochemical identification and quantification of neurotransmitters being a challenge in the ever-growing field of neuroelectronics, we aimed to facilitate the electrochemical selective detection of dopamine by functionalizing commercially available electrodes through the deposition of a thin film containing pre-formed gold nanoparticles. The influence of different parameters and experimental conditions, such as buffer solution, fiber material, concentration, and cyclic voltammetry (CV) cycle number, were tested during neurotransmitter detection. In each case, without drastically changing the outcome of the functionalization process, the selectivity towards dopamine was improved. The detected oxidation current for dopamine was increased by 92%, while ascorbic acid and serotonin oxidation currents were lowered by 66% under the best conditions. Moreover, dopamine sensing was successfully achieved in tandem with home-made triple electrodes and an in-house built potentiostat at a high scan rate mode.
Highlights
The World Health Organization (WHO) estimated in 2012 that 35.6 million people worldwide were suffering from neurological disorders which might be doubled by 2030 and more than tripled by 2050 due to the rapid aging of the population [1]
In this paper, we focused on electrode functionalization, effective when the concentration is high, which explains our intentional choice of high concentrations in and the potentiostat and functionalized electrodes were considered as a unique system
Our pre-formed gold nanoparticles are coated by a polymeric ligand but are still significantly smaller than the ones used previously in the literature [32]
Summary
The World Health Organization (WHO) estimated in 2012 that 35.6 million people worldwide were suffering from neurological disorders which might be doubled by 2030 and more than tripled by 2050 due to the rapid aging of the population [1]. To this day, it has not been possible to establish a concrete and a solid link between ionic or molecular exchanges and brain electric signal propagation, and degeneration and genesis of neurons in neurodegenerative diseases. They reported that they were able to sense a current of
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