Electrochemical Behaviour of Ti/Al2O3/Ni Nanocomposite Material in Artificial Physiological Solution: Prospects for Biomedical Application.

Alla Vorobjova,Tatiana Zubar,Dmitriy Shimanovich,Maxim Zdorovets,Sergey Trukhanov,Artem Kozlovskiy,Valery Fedosyuk,Alex Trukhanov,Denis Vinnik,Daria Tishkevich,Mengge Dong

doi:10.3390/nano10010173

Abstract

Inorganic-based nanoelements such as nanoparticles (nanodots), nanopillars and nanowires, which have at least one dimension of 100 nm or less, have been extensively developed for biomedical applications. Furthermore, their properties can be varied by controlling such parameters as element shape, size, surface functionalization, and mutual interactions. In this study, Ni-alumina nanocomposite material was synthesized by the dc-Ni electrodeposition into a porous anodic alumina template (PAAT). The structural, morphological, and corrosion properties were studied using x-ray diffraction (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM), and electrochemical techniques (linear sweep voltammetry). Template technology was used to obtain Ni nanopillars (NiNPs) in the PAAT nanocomposite. Low corrosion current densities (order of 0.5 µA/cm2) were indicators of this nanocomposite adequate corrosion resistance in artificial physiological solution (0.9% NaCl). A porous anodic alumina template is barely exposed to corrosion and performs protective functions in the composite. The results may be useful for the development of new nanocomposite materials technologies for a variety of biomedical applications including catalysis and nanoelectrodes for sensing and fuel cells. They are also applicable for various therapeutic purposes including targeting, diagnosis, magnetic hyperthermia, and drug delivery. Therefore, it is an ambitious task to research the corrosion resistance of these magnetic nanostructures in simulated body fluid.

Highlights

The use of nanomaterials in biomedicine reached significant achievements in the diagnostics, prevention, and therapy of a large number of illnesses
Nanocomposite materials are widely used in the field of different biomedical applications such as developing of materials to replace/regenerate tissues starting from tissue engineering with mesenchymal stem cells (MSCs) and biomimetic scaffolds [10], bone therapeutic applications [11,12,13], especially in regards to pathological fractures/injuries such as the one derived from osteoporosis [14]
In view of the aforesaid, the aim of this research is to study the electrochemical behavior of Ni nanopillars nanocomposite material (NiNPs) in porous anodic alumina template (PAAT) in artificial physiological solution (APS) (0.9% sodium chloride solution)

Summary

Introduction

The use of nanomaterials in biomedicine reached significant achievements in the diagnostics, prevention, and therapy of a large number of illnesses. This promising area uses various types of nanostructures Targeted drug delivery is a developing and promising technique for the treatment of cancer. This technique is based on the attachment of a therapeutic drug agent to the functional groups of the magnetic material nanostructure, its injection into the patient’s body (blood), and further transportation to the problem region. The role of inflammatory conditions in rehabilitation with biomaterials should be noted, as inflammatory phenomena may trigger the oxidative stress that would take advantage of perioperatory therapy [15]

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