Electrochemical behaviour of sertraline hydrochloride at a glassy carbon electrode and its determination in pharmaceutical products using osteryoung square wave voltammetry.

Abstract

In this study the electrooxidation of sertraline (STR) hydrochloride in pH 8 Britton-Robinson buffer (BRb) -methanol (MeOH) (1:1,v/v) supporting electrolyte was investigated using Osteryoung Square Wave Voltammetry (OSWV) with the glassy carbon electrode. OSWV is a rapid and sensitive electro-analytical technique for sertraline determination. This study indicated that sertraline was susceptible to oxidation. The effects of the supporting electrolyte, pH and scan rate on the anodic reactions performed in BRb and a scan rate interval 5 - 1000 mVs(-1) were investigated. Sertraline hydrochloride was oxidized irreversibly and diffusion controlled. OSWV was selected for the quantitative determination. Using optimized OSWV technique, the current was linear within a concentration range of 0.04-0.8 mM in pH 8 BRb which at the equivalent volume with MeOH. The applicability of the proposed method was shown by the successful analysis of sertraline in tablet dosage forms. Accuracy, precision, selectivity, sensitivity, within day and between days reproducibility of the method were investigated statistically. Application of the suggested method to pharmaceutical formulation is presented and compared with the UV spectrophotometric and HPLC methods. The results were found to be in a good agreement. No interference was observed from common pharmaceutical adjuvants.