Electrochemical behavior of diclofenac sodium at coreshell nanostructure modified electrode and its analysis in human urine and pharmaceutical samples

Abstract

In this contemporary consideration, a novel coreshell nanostructures modified sensor based on carbon electrode was engineered which achieved enhanced sensitivity towards Diclofenac. The electrochemical behavior and applications of Diclofenac (DCF) was determined by applying discrete voltammetric techniques. The surface characteristic was accomplished using atomic force microscopy (AFM). The proposed modified electrode showed strong electro catalytic activity and electro oxidation towards DCF with higher peak shift as equated to the bare electrode. The modified electrode possesses unique qualities such as fast transfer of electrons, constancy, repeatability and reproducibility. The various performances feigning the peak improvement such as accumulation time, pH, scan rate, modifier amount, and concentration impingements were considered. The electro-oxidation of DCF was studied by cyclic voltammetry (CV) and concentration effect was read using square wave voltammetry (SWV) technique in the concentration range of about 0.01 μM–300 μM. The limit of detection (LOD) was deliberated to be 3.41 × 10-8 M and quantification (LOQ) was 11.3 × 10-8 M, correspondingly. The pertinency of the purposed way was checked by quantification of DCF in pharmaceutic formulations and human urine samples. The mean of recovery of DCF in the tablet was 97.5%, with relative standard deviation of 0.7%.