Abstract
The analysis of synthetic / residual drugs is very important due to their systemic toxicity. Simple and rapid electrochemical degradation of nystatin drug was accomplished using constant current density electrolysis on platinum electrode. Electrochemical behavior of nystatin drug was investigated on different metallic electrodes by cyclic voltammetry. In saline solution, distinctive oxidation peak are observed on the lead and copper electrodes. The degree of electrochemical degradation reaches the maximum value of 100 % in 10 minutes on platinum electrodes. Thermal stability of nystatin drug was studied by simultaneous TG / DSC analysis. The thermogravimetric and heat flow curves indicated a relatively high stability up to 150 �C.
Highlights
The analysis of synthetic / residual drugs is very important due to their systemic toxicity
Most of the analytical methods used to study the determination of nystatin are based on electrochemical electrodes [2]; spectrophotometry [3]; densitometry [4]; micellar electrokinetic capillary chromatography [5] and liquid chromatography [6]
Electrochemical behavior of nystatin drug on metallic electrodes The electrochemical degradation processes of the organic compounds are strongly influenced by the nature of the electrode used, was studied the electrochemical degradation of Nystatin (Nyst) 5·10-5 mol·L-1, NaCl 10-1 mol·L-1 on different metallic electrodes: Cu, Ni, Pb and Pt
Summary
The analysis of synthetic / residual drugs is very important due to their systemic toxicity. Cyclic voltammograms of aqueous solution of nystatin drug in the presence of chloride ions were performed using a VoltaLab 40 and a three electrode one compartment electrochemical cell. Results and discussions Electrochemical behavior of nystatin drug on metallic electrodes The electrochemical degradation processes of the organic compounds are strongly influenced by the nature of the electrode used, was studied the electrochemical degradation of Nystatin (Nyst) 5·10-5 mol·L-1, NaCl 10-1 mol·L-1 on different metallic electrodes: Cu, Ni, Pb and Pt. In order to elucidate the electrochemical degradation mechanisms, the cyclic voltamograms
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