Electrocatalytic determination of dopamine in the presence of uric acid using an indenedione derivative and multiwall carbon nanotubes spiked in carbon paste electrode

Abstract

In the present study, a modified carbon paste electrode (CPE) containing multi-wall carbon nanotubes and an indenedione derivative(IMWCNT−CPE) was constructed and was successfully used for dopamine(DA) electrocatalytic oxidation and simultaneous determination of DA and uric acid (UA). Cyclic voltammograms of the IMWCNT−CPE show a pair of well-defined and reversible redox. The obtained results indicate that the peak potential of DA oxidation at IMWCNT−CPE shifted by about 65 and 185mV toward the negative values compared with that at a MWCNT and indenedione modified CPE, respectively. The electron transfer coefficient, α, and the heterogeneous electron transfer rate constant, k′, for the oxidation of DA at IMWCNT−CPE were calculated 0.4±0.01 and (1.13±0.03)×10−3cms−1, respectively. Furthermore, differential pulse voltammetry (DPV) exhibits two linear dynamic ranges of 1.9–79.4μM, and 79.4–714.3μM and a detection limit of 0.52μM for DA determination. Then IMWCNT−CPE was applied to the simultaneous determination of DA and UA with DPV. Finally, the activity of the modified electrode was also investigated for determination of DA and UA in real samples, such as injection solution of DA and urine, with satisfactory results.