Year-end Sale % OFF 
Abstract
The electrooxidation of cysteamine (CA) was studied by modified carbon nanotubes paste electrode in the presence of 3,4-dihydroxycinnamic acid (3,4-DHCA) using cyclic voltammetry, chronoamperometry and linear sweep voltammetry. Using the modified electrode, the kinetics of CA electrooxidation was considerably enhanced by lowering the anodic over-potential through a catalytic fashion. The mechanism of CA electrochemical behavior at the modified electrode surface was analyzed by various electrochemical methods in the presence of mediator. The prepared modified electrode showed voltammetric responses with high sensitivity for CA, making it very suitable for the detection of CA at trace levels. A linear dynamic range of 0.25-400 µmol L-1 for CA was obtained in buffered solutions with pH 7.0. The limit of detection was 0.09 µmol L-1.
Highlights
Cysteamine is an important thiol drug for the treatment of cystinosis.[1]
The results showed that the best cyclic voltammogram (CV) shape and current was achieved with 10.0% (m/m) multiwall carbon nanotubes (MWCNTs) and 90.0% (m/m) graphite
After multiwall carbon nanotubes (MWCNTs) were added to the carbon paste matrix, it can be seen that MWCNTs were distributed on the surface of electrode with special three-dimensional structure (Figure 1b), indicating that the MWCNTs were successfully modified on the Multiwall carbon nanotube paste electrode (MWCNTPE)
Summary
Cysteamine is an important thiol drug for the treatment of cystinosis.[1]. The deficiency of a cystine carrier in the lysosomal membrane leads to cystine accumulation within the lysosomes, crystallizing in vital organs such as the liver, kidney, spleen, intestines, and cornea.[2,3] A number of long term clinical trials have shown that cysteamine administration (as cysteamine hydrochloride) stabilizes renal function, delays glomerular deterioration and improves linear growth.[4]. Vol 24, No 1, 2013 of research articles published in recent years report many remarkable claims about the advantages of carbon nanotubes, such as increased voltammetric currents,[23-25] increased heterogeneous electron-transfer rates,[26] insignificant surface fouling of CNT-based electrodes,[27,28] and an apparent “electrocatalytic” effect towards the redox process of a wide variety of compounds.[29-33]. In this study, it was described initially the application of 3,4-dihydroxycinnamic acid as a suitable mediator in the electrocatalysis and voltammetric determination of CA in an aqueous buffer solution. Different amounts of the solution plus 10 mL of 0.10 mol L−1 buffer (pH 7.0) were used for analysis
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
