Electrically polarized hydroxyapatite with Sr containing barium titanate incorporated with mangiferin for enhanced osteogenic and antibacterial activity

Abstract

An electrically active ceramic composite of Ca10(PO4)6(OH)2 and BaSrTiO3 was studied for its possible therapeutic applications. This study offers an in-depth investigation into the material science aspects of composites, including their biological properties and dielectric interactions. The weight ratio of the mixed hydroxyapatite and ferroelectric barium strontium titanate was 60:40. The microstructure and phase composition of the composites were both characterized using X-ray diffraction analysis and scanning electron microscopy (SEM). As part of the in vitro study, mangiferin (MANG) was included in both unpolarized and polarized HA-BST composites. The MTT assay for cell viability showed enhanced osteoblast activity of the specimens. The polarized composite was found to be more effective than the unpolarized specimen in inhibiting the growth and attachment of Staphylococcus aureus. As a result, the polarized HA-BST-MANG composite has shown to be an effective bone substitute in encouraging osteoblast production and preventing bacterial infection.