Abstract
Sleep aids, anti-anxiety medications, anesthetics, alcohol, and neurosteroids all target GABAA receptors (GABAARs), which regulate the bulk of rapid inhibition in the mammalian brain. GABAA receptors are pentamers of α, β and γ subunits, with the γ2 subunit having two splice variants (γ2S and γ2L). These two variants are distinguished by 8 amino acid differences when integrated into the pentameric receptors. It been noted that they have assorted patterns of regional distribution during development and in the adult brain with the γ2L dominating in later stages of life.
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