ELASTIN CONDUIT FOR URETERAL REPLACEMENT IN A PORCINE MODEL

Abstract

We investigated the feasibility and biocompatibility of a homologous elastin base conduit as a ureteral substitute in the porcine model. In 13 female domestic swine, a 2.5 to 3-cm mid-segment of unilateral ureter was resected and replaced with the elastin conduit. At varying intervals (from 1 to 12 weeks), the animals were euthanized and the specimens were prepared for histologic evaluations. Twelve of 13 animals entered the end point in this study. One pig died peri-operatively due to anesthesia complication. The histologic study showed that the transitional epithelia cells completely lined the surface of the elastin conduit lumen at 4 weeks, and a progressive neovascularization infiltrated through elastin matrix. However, at 12 weeks after implantation, there was no evidence of smooth muscle cells regeneration. We also noticed the presence of submucosa hyperplasia and localized ossification on the grafts. The elastin conduit allows transitional urothelia cells regeneration without incrustation. It can be modified as a potential ureteral replacement.