Abstract
Summary (1) A method for measuring elasticity, breaking strain and other tensile properties of rabbit aortas was developed using a textile load-testing machine. (2) Rabbits were maintained on 1 % cholesterol diets for periods from 10–15 weeks. Thoracic aortas were dissected out and graded for atherosclerotic plaques. Elasticity, breaking strain and inelastic stretching constants were measured for normal and atherosclerotic aortas. (3) Elasticity of heavily involved atherosclerotic aortas (4.4 lb.-1) was significantly less than that of normal tissue (6.61b.-1). Breaking strain and inelastic stretching constants of atherosclerotic aortas were not however significantly different from normal values. (4) Visible changes in the surface appearance of the aorta occur before changes in elasticity can be detected. Measurement of elasticity changes does not therefore provide an earlier indication of plaque formation than visual observation.
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