Abstract
Scabies is a contagious parasitic skin disease caused by Sarcoptes scabiei. In Indonesia, this disease considerably remains a major problem in animal health, particularly in goats. The aim of this study is to investigate the effectivity of gamal leaves coconut oil extract (GLEC) for scabies treatment in goat. This research was divided into 2 parts: 1. Preparing Gamal Leaves Coconut Oil Extract (GLCE) which included 4 stages of study: collection of gamal leaves; measurement coumarin level in gamal leaves; gamal leaves extraction with coconut oil; and extract stability test and 2. Application of GLCE in goats includes 3 stages of study : artificial S. scabiei infestations in goats; GLCE treatment in goats with 3 concentrations (12.5%, 25%, 50%); and drug safety testing. The results showed that the concentration of coumarin in the gamal leaves which was effectively for scabies drugs was > 1000 ppm. The 12.5%, 25%, 50% of GLCE concentrations are safe as botanical acariside and can reduce 100% of S.scabiei mite populations after 4x, 3x and 2x treatment at 1 week intervals, respectively. The 50% concentration of GLCE is safe, most effective, efficient and stable in storage for scabies drug.
Highlights
Skabies merupakan penyakit parasit menular pada kulit yang disebabkan oleh Sarcoptes scabiei
In Indonesia, this disease considerably remains a major problem in animal health, in goats
The aim of this study is to investigate the effectivity of gamal leaves coconut oil extract (GLEC) for scabies treatment in goat
Summary
Beberapa penelitian tanaman herbal lain untuk skabies yang pernah dilaporkan antara lain adalah penggunaan salep TTO 5% pada kambing menunjukkan penurunan jumlah tungau secara nyata (88%) dengan pengobatan selama empat kali berturut-turut dalam interval satu minggu Manurung et al, 2007. Pembuatan ekstrak Minyak Daun Gamal (EMDG) dilakukan menurut Philipine Medicinal Plant (2009) yang dimodifikasi yaitu daun gamal segar dicacah halus atau diblender kemudian dicampur dengan minyak kelapa sawit selanjutnya dipanaskan sampai mendidih selama satu jam. Aplikasi ekstrak minyak daun gamal pada hewan coba (kambing) dibagi menjadi tiga tahap yaitu : Infeksi Buatan Tungau S. scabiei. Pengamatan dilakukan seminggu sekali selama enam minggu terhadap: 1) Penurunan jumlah tungau S. scabiei dalam tiap 2 cm kerokan kulit telinga dan badan; 2) Perubahan skor lesi kudis (pengelupasan keropeng); dan 3) Pertumbuhan rambut. Pertumbuh Rambut yang Rambut yang Rambut yang Rambut yang Tidak ada an rambut tumbuh e”80% tumbuh tumbuh tumbuh rambut yang pada permu- 50-80% pada 20-50% pada 10- 20% pada tumbuh pada kaan luka permukaan permukaan permukaan permukaan luka luka luka luka (
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