Abstract
Nephrotoxicity is a disorder of the kidneys that occurs when exposed to drugs or toxins. Pandan wangi leaves have antioxidant activity expected to give antinephrotoxicity effect. This aim of study is to determine the antinephrotoxicity effect of the ethanol extract of pandan wangi leaves (Pandanus amaryllifolius Roxb.) based on the decline of rat creatinine level induced by gentamicin. Eighteen male Wistar rats were divided into 6 groups. That is naive, negative control by Na-CMC 1%, positive control by the suspension of keto acids, and treatment group with ethanol extract of pandan wangi leaves at 125 mg/kgBW, 250 mg/kgBW and 500 mg/kgBW. Nephrotoxicity condition was induced by Gentamicin 80 mg/kgBW (ip) for seven days. The blood samples were taken and measured the serum creatinine levels on days 0, 8th and 22th by Human Analyzer. The results study showed that ethanol extract of pandan wangi leaves at 250 mg/kgBW and 500 mg/kgBW have the effect as antinephrotoxicity based on decreased creatinine levels.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
