Effectiveness of Boiled Cherry Leaf (muntingia calabura L) Toward Ureum Creatinine Serum of Wistar Strain Mice with Acute RenalFailure Model

Abstract

Renal failure is a clinical condition that is characterized by a decrease in kidney function with an indicator of changes in the levels of urea and creatinine. The purpose of this study is to determine the effectiveness of Boiled Cherry leaf (muntingia calabura L) on the reduction of ureum and creatinine levels. The objects in this study were 30 male Wistar strain rats aged 2-3 months with a weight of 180-200 grams. Rats were randomly grouped into 3 groups: the treatment group, positive control and negative control. The positive treatment and control group was induced gentamicin 0.3 cc IP / day for 7 days. Boiled water from 10 grams of cherry leaves (muntingia calabura) in 200 cc of boiling water to 100 cc was given as much as 3.6 cc orally for 7 days to the treatment group. Data were analyzed with SPSS version 24, One test ANOVA was performed to compare urea and creatinine levels. The results showed that there were significant differences in urea and creatinine levels between the treatment group and the positive control group (p <0.05). Urea and creatinine values between the treatment group and the negative control group were not different (p = 0.06). As Conclusion , boiled cherry leaves (muntingia calabura) has an effect on the reduction of urea and creatinine serum in male wistar strain rats with acute renal failure models.