Abstract
Single-cell RNA-seq has revolutionized our understanding of cellular heterogeneity in a wide spectrum of biological processes. Pioneering studies suggest complex mechanisms and division of labour employed by the bacterial pathogen Salmonella to subvert host cell functions during infection. Here we describe some of our findings from single-cell RNA-seq studies that have revealed and characterized heterogeneity between individual cells infected with this intracellular pathogen, and outline future challenges in this burgeoning field.
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