Abstract
The aim of this study was to evaluate the effect of CLA supplementation on antioxidant metabolism in healthy overweight/obese Korean individuals. We performed a randomized, double-blind, placebo-controlled trial, where 29 healthy overweight/obese (BMI≥23kg/m(2)) participants (2 men and 27 women) were randomly selected to receive placebo (n=15, 2.4g olive oil/day) or 2.4g/day CLA mixture (n=14, 36.9% of cis-9, trans-11 and 37.9% of trans-10, cis-12) for 8weeks. There were no significant differences in plasma total radical-trapping antioxidant potential (TRAP), lipid peroxidation (conjugated dienes), lipid-soluble antioxidant vitamin concentration, erythrocyte antioxidant enzyme (superoxide dismutase, catalase, glutathione peroxidase) activities, and leukocyte DNA damage between the CLA and placebo groups. The data suggest that short-term supplementation (8weeks) with CLA (2.4g/day) might have no significant effects on lipid peroxidation and antioxidant metabolism.
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