Abstract
Background and Aims : Air pollution is the fourth leading contributor to global mortality. Small particulate matter (PM) specifically increases circulating triglyceride (TG) levels, a cardiovascular (CV) risk factor. Apolipoprotein C-III (ApoC-III) is associated with TG-rich lipoproteins and inhibits lipase activity, thus increasing TG levels. The omega-3 fatty acid, eicosapentaenoic acid (EPA), reduces TGs and events in patients with high CV risk (REDUCE-IT). We measured the effects of EPA on expression of ApoC-III in pulmonary endothelial cells (PECs) during exposure to finely-sized and urban-sourced PMs.
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