Abstract
Egg oil from Portunus trituberculatus (Pt-egg oil) can overcome insulin resistance resulting from abundant bioactive lipids. However, its effects on obesity and gut microbiota were unclear. Here, we evaluated whether Pt-egg oil could improve obesity and gut microbiota or not in high-fat diet feeding mice. Results exhibited that Pt-egg oil markedly reduced body weight and adipose weight gain, improved lipid accumulation and circulatory cytokines, inhibited epididymal adipose cell size. Moreover, Pt-egg oil modified gut microbiota, involving decreases in the ratio of Firmicutes to Bacteroidetes, Proteobacteria, Actinobacteria, and increase in Verrucomicrobia phylum. Pt-egg oil reduced serum and fecal lipopolysaccharide (LPS) levels and down-regulated Toll-like receptor 4 pathway in both epididymal adipose and liver tissues. Meanwhile, Pt-egg oil increased short chain fatty acids and up-regulated of G-protein-coupled receptors in both epididymal adipose and liver tissues. These suggest that Pt-egg oil could be alternative food supplement for the prophylactic effects on anti-obesity and improvement in human gut health.
Highlights
Egg oil from Portunus trituberculatus (Pt-egg oil) can overcome insulin resistance resulting from abundant bioactive lipids
When treated with Pt-egg oil, dramatic decrease in epididymal adipose cell size was observed in high-fat diet (HFD)-feeding animals (P < 0.01)
Pt-egg oil reduced the numbers of Ruminiclostridium_5, Ruminiclostridium, Ruminococcaceae_UCG-013, Anaerotruncus, Oscillibacter, Faecalibaculum, norank_f_Erysipelotrichaceae, Helicobacter, unclasslfied_Coriobacteriaceae and Coriobacteriaceae_UCG-002, Bifidobactenium, and Desulfovibrio compared with obese mice
Summary
Egg oil from Portunus trituberculatus (Pt-egg oil) can overcome insulin resistance resulting from abundant bioactive lipids. We evaluated whether Pt-egg oil could improve obesity and gut microbiota or not in high-fat diet feeding mice. Pt-egg oil reduced serum and fecal lipopolysaccharide (LPS) levels and down-regulated Toll-like receptor 4 pathway in both epididymal adipose and liver tissues. Pt-egg oil increased short chain fatty acids and upregulated of G-protein-coupled receptors in both epididymal adipose and liver tissues. These suggest that Pt-egg oil could be alternative food supplement for the prophylactic effects on anti-obesity and improvement in human gut health. Pt-egg oil remarkably reduced blood glucose and serum insulin levels in HFD-fed mice[14] It is still unclear the influences of Pt-egg oil on obesity and the regulation of gut bacteria. We investigated the effects of Pt-egg oil on anti-obesity and gut microbiota in HFD-fed mice, and clarify its mechanism on alleviation of obesity through regulation of microbial community and secondary metabolites
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