Abstract
Efficient synthesis of novel bis(dihydropyrano[2,3c]pyrazoles), bis(4H-chromenes) and bis(dihydropyrano[3,2-c]chromenes) with amide functionality
Highlights
The amide group is one of the most popular and reliable functionalities in organic chemistry
The favorable properties of amide groups, such as high polarity, stability and conformational diversity stimulated authors to search for improved methods for the synthesis of novel amide-based molecules.[1,2,3,4,5,6,7]
We reported extensively on the Michael addition reaction[23,24,25,26] as well as the chemistry of bis-(heterocycles) whose heterocyclic moieties were linked via different aliphatic and aromatic spacers.[8,24,26,27,28,29,30,31,32,33]
Summary
The amide group is one of the most popular and reliable functionalities in organic chemistry. A subsequent MCR of 12a with two equivalents of both of malononitrile and 5-methyl-2,4-dihydro-3Hpyrazol-3-one or dimedone in ethanol heated at reflux in the presence of piperidine gave bis(1,4dihydropyrano[2,3-c]pyrazole-5-carbonitrile) 8a and bis(4H-chromene-3-carbonitrile) 9a in 82 and 65% yields, respectively.
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