Abstract
An efficient synthesis of novel bis(1-(cyclohexylamino)-1-oxoalkyl or aryl) fumarates (4a–k), considering as organic building blocks for natural products and drugs, via the reaction of fumaric acid, various aldehydes and cyclohexyl isocyanide in water using one-pot three-component approach under mild condition and without catalyst is described. This rapid method produced the products in short reaction times (10–15 min) and excellent yields (85–95 %) at room temperature. The structures of the products were deduced from their elemental analyses and spectroscopic data. .
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