Abstract
Abstract The reaction of methyl (Z)-9,10-epoxy-12-oxoocta-decanoate (2) with ammonium azide, generated in situ from sodium azide and ammonium chloride in aqueous ethanol affords methyl 8-(5-hexylfuran-2-yl)octanoate (1b) in 98% yield. Compound 1b was also prepared in >90% yield by reacting compound 2 with the following Lewis acids: aluminium(III) chloride, tin(IV) chloride, zinc(II) chloride under reflux in benzene or dichloromethane; or at ambient temperature with tin(II) bromide or hydrated tin(II) chloride in dichloroethane.
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