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Abstract
AbstractFrom the ethanol extract of the stem bark of Tabebuia cassinoides (Lam.) DC (Bignoniaceae), Kingston and Rao [1] isolated two new furonaphthoquinones 6 and 7 that showed activity in KB cell culture assay (ED50 1.0 and 2.0 μg/ml, respectively). These values may be significant since lapachol, which has an ED50 value of 4.4 μg/ml in the same assay, showed sufficient in vivo activity to reach clinical trial at the National Cancer Institute of the United States. The syntheses of these compounds (6 and 7) were realized in 36% overall yield starting from furan and phthalic anhydride.
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