Abstract
In this work we describe a simple and rapid method for the synthesis of a series of pyrano[4,3-b]pyran derivatives by a three-component reaction between 4‑hydroxy-6-methylpyran-2-one, malononitrile and a variety of aromatic and heteroaromatic aldehydes. The reactions are carried out at reflux of a water/ethanol mixture in the presence of 10 mol% of pyridinium p-toluenesulfonate as catalyst with excellent yields of expected products. The antimicrobial and anti-Alzheimer's activities of the prepared products were evaluated and some molecules gave interesting results. In addition, theoretical studies such as Density Functional Theory (DFT), IR and UV–visible spectra and molecular docking have also been carried out. Moreover, the molecular structure of one compound was confirmed by X-ray diffraction analysis with its Hirshfeld surface analysis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.