Abstract
A novel methodology utilizing the aza-Payne rearrangement and O, N-intramolecular acyl transfer reactions for the synthesis of peptidomimetics containing hydroxyethylamine dipeptide isosteres (HDIs) is described. This methodology is useful for the stereoselective synthesis of HDI-containing pseudopeptides, and applicable to combinatorial chemistry using solid-phase techniques.
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More From: Journal of the Chemical Society, Perkin Transactions 1
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