Abstract
Although double-stranded RNA-induced gene silencing (or RNA interference, RNAi) has proven to be a useful tool for genetic manipulation in a wide range of organisms, its use in mammalian cells has been very limited until recently. More than a year ago, Tuschl and colleagues reported the effective use of short interfering RNAs (siRNAs) in mammalian cells, possibly by bypassing the antiviral response of cells usually triggered by dsRNA.
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