Abstract
AbstractA non‐hydrogenolytic mild deprotection strategy for stable benzyl protection of hydroxyl group is one of the long‐cherished goals in multistep synthesis involving carbohydrates or compounds with multiple hydroxyl groups. A greener organo‐photocatalytic method has been developed for mild and efficient visible light catalytic deprotection of benzyl group from benzyl ether and benzyl ester. The newly developed method in ambient condition with only 1 mol% of catalyst loading can efficiently remove highly stable benzyl protection from ethers and esters of wide substrate scope with excellent functional group tolerance, thus proved to be suitable for final stage deprotection. Employment of molecular oxygen as terminal oxidant and excellent yield in the multigram scale reaction signifies the eco‐friendliness, robustness and industrial applicability of the method.
Published Version
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