Abstract
Assessment of DNA and ligand interaction is a great challenge to the medical researchers and drug industries since the accurate mapping of DNA and ligand plays an important role in associating drugs for suitable diseases. The primary objective of this research work is to develop an efficient model for predicting the best DNA and Ligand mapping. In this research work, 500 instances of DNA and drugs used for cancer and non-cancer diseases from the National Centre for Biotechnology Information (NCBI) were considered for analysis. Binding energy is one of the important measures to predict and finalize the best DNA and ligand interaction. Existing methods used for the docking process such as Simulated Annealing (SA), Lamarckian Genetic Algorithm (LGA), Genetic Clustering (GC), Fuzzy C-means clustering (FCM), and Genetic Clustering with Multi swarm Optimization (GCMSO) were applied for all 500 instances. These algorithms failed to produce better binding energy due to a lack of optimization in the existing approaches. Optimization methods play a major role in predicting accurate DNA ligand docking. Hence, this research proposes an efficient architecture using Fuzzy C-Means Clustering with Glowworm Swarm (FCMGSO) optimization method for accurate analysis of the DNA-ligand docking process. Results are proving that the proposed FCMGSO algorithm shows less binding energy than other existing methods in all instances of samples considered from the NCBI dataset. Communicated by Ramaswamy H. Sarma
Published Version
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