Efficient and green synthesis of trisubstituted imidazoles by magnetically nanocatalyst and microwave assisted

doi:10.33945/sami/ajgc/2019.4.9

Abstract

Fe3O4 magnetic nanoparticles (Fe3O4 MNPs) were prepared and used as an eco-friendly, reusable, low-cost and efficient catalyst for the synthesis of 2,4,5-trisubstituted imidazoles via three-component reaction of aromatic aldehydes with benzil and ammonium acetate under low power microwave irradiation and solvent-free condition. This one-pot procedure is very simple with good to excellent yields. Easy separation of Fe3O4 MNPs from the reaction mixture by an external magnet and the reusability of the catalyst are the considerable points of the reaction.

Highlights

Multi-substituted imidazoles are an important class of heterocyclic compounds with wide biological and pharmaceutical applications [1,2,3]
Fe3O4 MNPs have attracted a great attention in many different fields due to their intrinsic properties including, high surface area, low toxicity, super-paramagnetic behavior, and easy separation and recovery from the reaction medium by magnetic decantation [27,28,29]
Incorporation of the cyclo condensation pathway with MW irradiation and property of Fe3O4 MNPs causes imidazoles be achieved in higher yields and shorter time

Summary

Introduction

Multi-substituted imidazoles are an important class of heterocyclic compounds with wide biological and pharmaceutical applications [1,2,3]. The use of microwave for the synthesis of organic compounds under solvent-free condition has proved to be efficient, safe and environmentally benign technique, with shorter reaction time, high yields, and easier work-up [23, 30,31,32]. Incorporation of the cyclo condensation pathway with MW irradiation and property of Fe3O4 MNPs causes imidazoles be achieved in higher yields and shorter time. In this research study, we introduced the Fe3O4 MNPs as a green heterogeneous catalyst for the synthesis of 2,4,5-trisubstituted imidazoles via the three-component reaction of various aromatic aldehydes with ammonium acetate and benzil under solvent-free condition and low power microwave irradiation (Scheme 1)

Methods

Results

Conclusion