Abstract
The preparation of the proline analogue (2 S,3a S,7a S)-octahydroindole-2-carboxylic acid (Oic) and its enantiomer, (2 R,3a R,7a R)-Oic, is described. A racemic precursor has been synthesized in good yield and subjected to HPLC resolution on a chiral column. The high efficiency of both the synthetic and chromatographic procedures has allowed the isolation of multigram quantities of each amino acid in enantiomerically pure form and suitably protected for use in peptide synthesis.
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