Abstract
Purpose of the study. Evaluate the efficiency of permanent post-dilution online hemodiafiltration therapy in combination with the prescription of keto analogues of amino acid at a dose of 0,2 g/kg of ideal body weight/day to correct protein-energy malnutrition in hemodialysis patients with adequate intake of essential nutrients. Patients and methods. A total of 645 patients with terminal renal failure received programmed hemodialysis, of which there were 300 men and 345 women aged 58,8 ± 6,9 years. All patients received treatment with programmed GD for 6,9 ± 2,1 years. All patients underwent a comprehensive assessment of nutritional status. The level of leptin and interleukin-6 serum was determined. Patients with signs of protein-energy malnutritian (PEM) were divided into three groups, depending on the method of PEM correction. Results. The study showed the efficiency of postdilution online hemodiafiltration therapy on an ongoing basis in combination with keto-analogues of amino acids at a dose of 0,2 g/kg of ideal body weight/day for correction of PEM in hemodialysis patients. Conclusion. The post-dilution online hemodiafiltration therapy combined with keto-analogues of amino acid at a dose of 0.2 g /kg of ideal body weight/day can be considered one of the pathogenetically grounded methods for correcting PEM in patients receiving programmed hemodialysis with adequate intake of essential nutrients.
Highlights
All patients underwent a comprehensive assessment of nutritional status
The study showed the efficiency of postdilution online hemodiafiltration therapy on an ongoing basis in combination with keto-analogues of amino acids at a dose of 0,2 g/kg of ideal body weight/day for correction of protein-energy malnutritian (PEM) in hemodialysis patients
The post-dilution online hemodiafiltration therapy combined with keto-analogues of amino acid at a dose of 0.2 g /kg of ideal body weight/day can be considered one of the pathogenetically grounded methods for correcting PEM in patients receiving programmed hemodialysis with adequate intake of essential nutrients Keywords: protein-energy malnutritian, hemodialysis, post-dilution online hemodiafiltration, ketoanalogues of amino acids
Summary
В настоящем одним из основных методов коррекции БЭН у данной когорты пациентов является изменение обычного рациона пациента за счет увеличения дозы потребления пищевого белка с 1,1 до 1,4 г/кг идеальной массы тела/сутки [4]. Одним из наиболее перспективных методов коррекции БЭН у пациентов, получающих лечение программным гемодиализом, следует считать перевод пациента на постоянную терапию постдилюционной онлайн-гемодиафильтрации с обязательным контролем потребления пищевого белка (1,1 г белка/кг идеальной массы тела/сутки) и добавлением к терапии препаратов кетоаналогов аминокислот в дозе 0,2 г/кг идеальной массы тела/сутки.
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