Abstract
Aim. To evaluate the effectiveness of combined post-dilution online hemodiafiltration therapy and ketoanalogue amino acid medications at a dose of 0.2 g/kg of ideal body weight/day for sarcopenia-correcting interventions in patients on hemodialysis with adequate intake of essential nutrients. Materials and methods. In total, 645 patients undergoing hemodialysis were examined. Nutritional status of all patients was evaluated to identify pre-sarcopenia and sarcopenia. In addition, leptin and interleukin-6 serum levels were determined. The patients with signs of sarcopenia were divided into three groups depending on the treatment method. Results. We demonstrated the effectiveness of combined post-dilution online hemodiafiltration therapy and ketoanalogue amino acids at a dose of 0.2 g/kg of ideal body weight/day for correction of sarcopenia in patients on hemodialysis. Conclusion. Combined therapy with post-dilution online hemodiafiltration therapy and ketoanalogue amino acids at a dose of 0.2 g/kg of ideal body weight/day is regarded as a pathogenetically grounded method for correction of sarcopenia in patients on hemodialysis with adequate intake of essential nutrients. (For citation: Jakovenko AA. Current treatment methods for sarcopenia in patients undergoing hemodialysis. Urologicheskie vedomosti. 2018;8(2):36-42. doi: 10.17816/uroved8236-42).
Highlights
The patients with signs of sarcopenia were divided into three groups depending on the treatment method
We demonstrated the effectiveness of combined postdilution online hemodiafiltration therapy and ketoanalogue amino acids at a dose of 0.2 g/kg of ideal body weight/day for correction of sarcopenia in patients on hemodialysis
Одно из проявлений белково-энергетической недостаточности (БЭН) у пациентов, получающих лечение программным гемодиализом, представлено дефицитом массы скелетной мускулатуры, сопровождающимся снижением ее функциональной активности [1, 2]
Summary
Current treatment methods for sarcopenia in patients undergoing hemodialysis. Aim. To evaluate the effectiveness of combined post-dilution online hemodiafiltration therapy and ketoanalogue amino acid medications at a dose of 0.2 g/kg of ideal body weight/day for sarcopenia-correcting interventions in patients on hemodialysis with adequate intake of essential nutrients. The patients with signs of sarcopenia were divided into three groups depending on the treatment method. We demonstrated the effectiveness of combined postdilution online hemodiafiltration therapy and ketoanalogue amino acids at a dose of 0.2 g/kg of ideal body weight/day for correction of sarcopenia in patients on hemodialysis. Combined therapy with post-dilution online hemodiafiltration therapy and ketoanalogue amino acids at a dose of 0.2 g/kg of ideal body weight/day is regarded as a pathogenetically grounded method for correction of sarcopenia in patients on hemodialysis with adequate intake of essential nutrients
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