Abstract
The goal of our work was to develop acomposition for antimicrobial photodynamic inactivation (aPDI) of anaerobic periodontopathogenic pathogens. The three test groups were as follows: light plus doxycycline (L+DOX+), light plus doxycycline and hypericin (L + DOX + HYP +), and control groups. aPDI was evaluated by the number of grown colonies on adense nutrient medium after 12, 24, and 48 hours of bacterial suspension cultivation. Based on the results of microbiological studies, the combined photosensitising effect of asubinhibitory dose of doxycycline and hypericin was determined. The delay of growth of A. israelii, P. melaninogenica in the second group (L+DOX+HYP) was significantly significant compared to the first group (L+DOX+), and the statistical difference in colony formation activity was found for both gram-positive and gram-negative cultures (p<0.05). aPDT is apromising therapeutic alternative for the local treatment of purulent-inflammatory diseases of various localisation caused by antibiotic-resistant bacteria, including in the oral cavity (Fig. 3, Ref.57). Text in PDF www.elis.sk Keywords: peri-implant diseases, photodynamic therapy, photosensitiser, anaerobic bacteria.
Published Version
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