Abstract
Burns are soft tissue injuries that require particular care for wound healing. Current tissue engineering approaches are aimed at identifying the most efficient treatment combinations to restore the tissue properties and function by using adapted scaffolds or delivery platforms for tissue repair and regeneration by triggering molecules. To reduce the inflammation associated with skin burns, the addition of an anti-inflammatory factor in these scaffolds would greatly increase the quality of the therapy. Therefore, this study is aimed at obtaining and validating a novel multiparticulate system based on a collagen matrix with controlled delivery of flufenamic acid anti-inflammatory drug for burn wound healing applications. In this work, we have characterized the properties and biocompatibility of these multiparticulate drug delivery systems (MDDS) and we have demonstrated their efficiency against burns and soft tissue lesions, particularly when the drug was microencapsulated, and thus with a controlled release. This study contributes to the advancement in therapy of burns and burn wound healing applications.
Highlights
Skin burns are tissue injuries generally caused by heat due to the contact with boiling liquids, hot solids, or flames
The healing process of the thermal burns comprises four overlapping phases including an initial phase of tissue homeostasis activated in the first couple of minutes after injury followed by posttraumatic inflammation and, in a couple of days, by the proliferation and skin remodeling phases [2]
To reduce the burst release effect and to provide a controlled drug release, we propose in this study the microencapsulation of an anti-inflammatory drug in biodegradable polymeric supports which results in topical multiparticulate drug delivery systems (MDDS)
Summary
Skin burns are tissue injuries generally caused by heat due to the contact with boiling liquids (scalds), hot solids, or flames. Thermal burns are complex processes that demand careful guided treatment to promote wound healing, reestablishing the immune barrier, and fast tissue regeneration with minimum scaring. The healing process of the thermal burns comprises four overlapping phases including an initial phase of tissue homeostasis activated in the first couple of minutes after injury followed by posttraumatic inflammation and, in a couple of days, by the proliferation and skin remodeling phases [2]. The first two phases of activated postinjury are critical for the wound healing evolution and scaring. The posttraumatic inflammatory phase is generally initiated by some cytokines such as tumor necrosis factor (TNF-α), interleukin-1 (IL-1), and interleukin-6 (IL-6) to promote local inflammation with neutrophil extravasation and macrophage activation. An impaired inflammatory process prolonged local pain and stimulates the cellular secretion of extracellular matrix with consequences on thick scars [2, 3]
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