Efficacy, toxicity and prognosis analysis of three-dimensional conformal radiotherapy combined with concurrent chemotherapy for locally advanced cervical cancer

Abstract

Objective To explore the efficacy, toxicity and prognosis of three-dimensional conformal radiotherapy combined with concurrent chemotherapy for locally advanced cervical cancer. Methods From January 2014 to January 2015, 96 patients with locally advanced cervical cancer in Yuncheng Central Hospital were selected and randomly divided into radiotherapy group and concurrent chemoradiotherapy group according to the digital table, with 48 cases in each group.The radiotherapy group received CT based three-dimensional conformal radiotherapy and three-dimensional 192Ir after loading irradiation technology, the concurrent chemotherapy group received docetaxel plus cisplatin chemotherapy synchronous three-dimensional conformal radiotherapy and three-dimensional 192Ir after loading irradiation technology.The clinical effect, 2-year survival rate, liver function injury, leukopenia and incidence of side effects, survival of patients and Karnofsky score before and after treatment were compared between the two groups. Results The effective rate of chemoradiotherapy of the concurrent chemoradiotherapy group was 75.00%, which was higher than 50.00% of the radiotherapy group (χ2=4.181, P 0.05). Before treatment, the living conditions and Karnofsky score had no statistically significant differences between the two groups (all P>0.05). After treatment, the survival and Karnofsky score improved more significantly in the concurrent chemoradiotherapy group, the differences were statistically significant(all P<0.05). Conclusion The curative effect of three dimensional conformal radiotherapy combined with concurrent chemotherapy on locally advanced cervical cancer is definite, and it can improve the prognosis of patients with high safety.As to liver function damage, leukocyte depletion and other toxic side effects, there are no statistically significant differences between two groups, so it is worthy of popularizing. Key words: Cervical cancer, advanced; Three dimensional conformal radiotherapy; Concurrent chemotherapy; Toxic and side effects